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KMID : 0369820040340050401
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Jorunal of Korean Pharmaceutical Sciences
2004 Volume.34 No. 5 p.401 ~ p.406
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Preparation and Drug Release of All-Trans Retinoic Acid-Loaded Poly(L-lactic acid) Nanoparticles
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채지만/Chae JM
이경만/김인숙/이용복/신상철/오인준/Lee KM/Kim IS/Lee YB/Shin SC/Oh IJ
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Abstract
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To develop an intravenous delivery system of all-trans retinoic acid (ATRA) for the cancer therapy, poly(L-lactic acid) nanoparticles were prepared and characterized. Emulsification-solvent evaporation method was chosen to prepare submicron sized nanoparticles. Spherical nanoparticles less than 200 nm in diameter with narrow size distribution were pre-pared, and the entrapment efficiency of drug was more than 95%. The endothermic peak at 183°C and X-ray crystallographic peak of ATRA appeared in the nanoparticle system, suggesting the inhibition of crystallization of ATRA by polymer adsorption during the precipitation process. ATRA was released at 37℃ for 60 days and the release rate was dependent on the concentration of drug incorporated in the nanoparticles. While ATRA was unstable in the light, it was very stable at 4℃. These results suggest the usefulness of PLA nanoparticles as a sustained and prolonged release carrier for ATRA.
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KEYWORD
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Poly(L-lactic acid), All-trans retinoic acid, Nanoparticles, Prolonged release
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